Largest Employers
| Company | County | Total Employees | Description |
| Y-12 National Security Complex | Roane | 10,986 | Refurbishing nuclear weapon components and storage and recycling of nuclear material. |
| Covenant Health | Regional | 9,792 | Health care system |
| The University of Tennessee - Knoxville | Knox | 9,384 | State university |
| Knox County Schools | Knox | 8,082 | Public education system |
| Wal-Mart Stores, Inc. | Regional | 5,998 | Discount stores and wholesale clubs |
| University of Tennessee Medical Center (UHS) | Knox | 5,458 | Health care system |
| DENSO Manufacturing Tennessee, Inc. | Blount | 5,350 | Advanced automotive components and systems |
| Clayton Homes, Inc. | Regional | 4,883 | Manufactured and modular homes; financier & insurer of manufactured homes |
| Oak Ridge National Laboratory | Roane | 4,876 | Research and Development |
| Dollywood Co./Dollywood Splash Country | Sevier | 4,500 | Theme park and water park |
| State of Tennessee - Regional Offices | Knox | 3,286 | State administrative offices |
| K-VA-T Food Stores (Food City) | Regional | 3,104 | Grocery stores and pharmacies |
| Sevier County Schools | Sevier | 3,000 | Local public education system |
| Tennova Healthcare | Regional | 2,900 | Health care system |
| Kroger Co. | Regional | 2,651 | Grocery stores |
| Blount Memorial Hospital | Blount | 2,647 | Area hospital |
| City of Knoxville | Knox | 2,644 | Municipal government |
| Roark Capital Group | Regional | 2,627 | Fast food restaurants |
| Knox County Government | Knox | 2,500 | County government |
| Tanger Five Oaks | Sevier | 2,500 | Retail |
| Team Health, Inc. | Knox/Blount | 2,260 | Health care providers |
| Pilot Flying J | Regional | 1,893 | Retail convenience stores and travel centers |
| East Tennessee Children's Hospital | Knox | 1,847 | Area children's hospital |
| Yum! Brands RSC | Regional | 1,824 | Fast food restaurants |
| UCOR | Roane | 1,816 | Engineering, environmental management & clean-up |
| Cracker Barrel Old Country Store, Inc. | Regional | 1,729 | Restaurants and general stores |
| McGhee Tyson ANG Base | Blount | 1,728 | Air National Guard unit |
| Blount County Schools | Blount | 1,701 | public education system |
| CVS Caremark Corp. | Knox | 1,594 | Drugstores and pharmaceutical distribution |
| Summit Medical Group, PLLC | Regional | 1,556 | Primary care physician group |
| Copper Cellar Corp. | Knox | 1,540 | Full-service restaurants |
| Brothers Management | Knox | 1,500 | McDonald's franchise |
| The Home Depot, Inc. | Regional | 1,478 | Home improvement warehouses and building supplies |
| Elavon | Knox | 1,476 | Electronic payment, processing service center |
| United Parcel Service (UPS) | Knox | 1,450 | Shipping and delivery operation |
| Jefferson County Schools | Jefferson | 1,348 | Public school system |
| Connor Concepts | Regional | 1,330 | Full Service Restaurants: The Chop House, Connor's Steaks & Seafood |
| Tennessee Valley Authority (TVA) | Knox | 1,326 | Regional power authority & development agency |
| Burleson Brands | Regional | 1,325 | Full-service restaurants: Aubrey's, Sunspot, Bistro by the Tracks, Barley's Taproom, Stefano's Pizza |
| Lowe's Home Improvement | Regional | 1,230 | Home improvement warehouses and building supplies |
| JTEKT Automotive TN-Vonore Co. | Monroe | 1,200 | Automotive steering systems |
| Darden Restaurants | Regional | 1,155 | Full-Service Restaurants: Red Lobster, Olive Garden, Longhorn Steakhouse, Cheddar's |
| Hilton Worldwide | Regional | 1,110 | Hotel group |
| Knoxville Utilities Board (KUB) | Knox | 1,106 | Local utilities provider |
| England Furniture | Claiborne | 1,100 | Furniture manufacturer |
| Old Dominion Freight Line | Regional | 1,100 | Transportation - trucking |
| U.S. Postal Service | Knox | 1,060 | Mail service |
| Anderson County Schools | Anderson | 1,050 | public education system |
| Broadway Electric Service | Knox | 1,047 | Construction - electrical contractor |
| Target Corp. | Regional | 1,045 | Discount stores |
| Pellissippi State Technical Community College | Knox | 1,019 | Two-year technical community college. |
| Oak Ridge Associated Universities | Anderson | 1,017 | University consortium, partnerships between scientific research, government & industry |
| Monroe County Schools | Monroe | 1,009 | Public school system |
| Newell Rubbermaid | Blount | 1,000 | Manufacturing - plastic office accessories |
| Collier Restaurant Group | Sevier | 989 | Restaurant operations |
| Roane County Schools | Roane | 950 | Public education system |
| Discovery Inc. | Knox | 937 | Cable networks - HGTV, Food Network, Do-It-Yourself, Fine Living & GAC |
| Vanderbilt Mortgage & Finance | Blount | 926 | Manufactured homes financing |
| University Physicians Association Inc. | Knox | 920 | Physicians group |
| Keurig Green Mountain | Knox | 900 | Manufacturer/distributor of single-cup beverages & brewers |
| Arconic | Blount | 898 | Aluminum beverage can sheets |
| Aisin Automotive Casting Tennessee Inc. | Anderson | 867 | Manufacture, casting, machining & assembly of timing chain covers, pistons, pumps, VVT's |
| Helen Ross McNabb Center | Knox | 850 | Provider of mental health care, addiction recovery & social services |
| Southeast Foods Co., LLC/Pennant Foods | Regional | 830 | Fast food restaurants |
| Dollar General Corp. | Regional | 824 | Retail trade - discount stores |
| Texas Roadhouse | Regional | 810 | Full Service Restaurants |
| Choice Hotels | Regional | 806 | Hotel groups |
| Charles Blalock & Sons, Inc. | Sevier | 805 | Hot and cold mix asphalt; ready-mix concrete |
| Eagle Bend Manufacturing | Anderson | 800 | Manufactures auto body parts |
| OrthoTennessee | Knox | 800 | Health care |
| SL Tennessee | Anderson | 800 | Manufacture gear shift assemblies, park brake levers, head & rear lights |
| SumiRiko Tennessee, INC. (DTR) | Claiborne | 800 | Rubber automobile hose |
| InterContinental Hotels | Regional | 799 | Hotel group |
| DeRoyal Industries | Knox | 785 | Manufactures medical devices and healthcare products |
| Belk, Inc. | Regional | 784 | Department stores |
| First Horizon Bank | Regional | 782 | Banks |
| ADT Security Services | Knox | 780 | Security system monitoring |
| Blount County Government | Blount | 774 | County government |
| Restaurant Brands Intl. | Regional | 760 | Fast food restaurants: Burger King, Popeye's |
| Chick-fil-A, Inc. | Regional | 749 | Fast food restaurants |
| Quality Home Health | Knox | 744 | Health Services - home health providers |
| Cherokee Health Systems | Knox | 739 | Health care service |
| Brunswick Boat Group & Sea Ray Boats, Inc. | Knox/Monroe | 728 | Fiberglass pleasure boats |
| Diverse Concepts, Ltd. | Regional | 701 | Full service restaurants: Blue Moose, Bullfsih, Carino's, Harrison's, Lakeside, Mellow Mushroom, Parkside, Timberwood |
| Subway | Regional | 699 | Fast food restaurants |
| Dine Brands Global | Regional | 690 | Full service restaurants: Applebee's, IHOP |
| Oak Ridge City Schools | Anderson | 689 | Local public education system |
| Kimberly-Clark Corp. | Knox/Loudon | 687 | Paper towels and bath tissue |
| Regal Entertainment Group | Knox | 664 | Movie theaters |
| Union County Schools | Union | 663 | Public school system |
| 21st Mortgage Corp. | Knox | 651 | Financing and servicing of manufactured home loans |
| Jewelry Television | Knox | 650 | Satellite-based gem/jewelry home-shopping cable network |
| Sevier County Government | Sevier | 650 | County government |
| Maryville City Schools | Blount | 641 | Government - Public School System |
| Walgreens | Regional | 633 | Pharmacies and convenience stores |
| Grainger Co Schools | Grainger | 626 | Public education system |
| Wyndham Hotel Group | Regional | 620 | Hotel group |
| Bojangles Restaurants | Regional | 613 | Fast food restaurants |
| AT&T, Inc. | Regional | 607 | Telecommunications provider - telephone and internet. |
| Loudon County Schools | Loudon | 574 | public education system |
| Sitel | Anderson/Knox | 563 | Global customer interaction solutions provider |
| Publix Super Markets | Regional | 560 | Grocery stores |
| Bloomin' Brands, Inc. | Regional | 550 | Full service restaurants: Bonefish Grill, Carrabba's, Fleming's, Outback |
| Monterey Mushrooms, Inc. | Loudon | 550 | Mushrooms |
| Harris Restaurant Group | Regional | 544 | Fast food restaurants |
| Accenture Hospitality Services | Blount | 541 | Financial shared services center for Marriott International, Inc. |
| Shoney's Restaurants | Knox | 540 | Full-service restaurants |
| Carlex Glass Co. | Monroe | 539 | Manufactures automotive glass |
| Starbucks | Regional | 532 | Coffee shops |
| Wilderness in the Smokies | Sevier | 530 | Hotel & water park complex |
| Comcast of the South | Knox | 526 | Broadband telecommunications services |
| National Fitness Center/Court South | Knox | 526 | Health club |
| Hillcrest Healthcare Communities, Inc. | Knox | 525 | Long-term care, assisted living, short-term & long-term rehab services |
| U.S. Cellular Corp. | Knox | 523 | Cell phone, data systems and customer service center |
| Presbyterian Homes of TN | Knox | 511 | Retirement communities and nursing homes |
| Mastercraft Boat Co | Monroe | 510 | Manufacturing - fiberglass leisure boats |
| Cellular Sales | Knox | 508 | Service - largest Verizon wireless dealer |
| Anderson County Government | Anderson | 507 | County government |
| Domino's Pizza | Regional | 504 | Fast food restaurants |
| Siemens Healthcare | Knox | 502 | Clinical imaging, preclinical & biomarker solutions |
| Fee Hedrick Family Entertainment | Sevier | 501 | Entertainment attractions |
| Averitt Express | Knox | 500 | Transportation - rrucking |
| Bush Brothers & Co | Knox, Jefferson | 500 | Manufacturing-Bush Beans and pet food |
| Commercial Vehicle Group | Monroe | 500 | Manufactures seats for heavy trucks & motorcoaches |
| Science applications International Corp. (SAIC) | Anderson | 500 | Science & engineering consulting, energy, national security |
| Waffle House | Regional | 494 | Fast food restaurants |
| City of Oak Ridge | Anderson | 480 | Municipal government |
| ConAgra | Cocke | 475 | Beans, tomato products |
| Ruby Tuesday, Inc. | Blount | 475 | Full-service restaurants |
| O'Charley's Inc. | Regional | 473 | Full service restaurant |
| SunTrust Bank | Regional | 471 | Banks |
| Roane State College | Regional | 467 | 2 year community college |
| Ingles Markets, Inc. | Regional | 463 | Grocery stores |
| Goodwill Industries | Regional | 451 | Service-donation centers; thrift stores |
| American Book Co. | Knox, Jefferson | 450 | Wholesale trade - books |
| Crete Carrier Corp | Loudon | 450 | Transportation - trucking |
| Exedy America Corp. | Knox | 450 | Automotive parts - torque converters |
| FedEx (Express, Freight & Ground) | Knox | 450 | Package distribution - motor freight |
| ORNL Federal Credit Union | Regional | 449 | Credit union |
| Krystal Co. | Regional | 443 | Fast food restaurants |
| Weigel's Farm Stores Inc. | Knox | 441 | Service stations and convenience stores |
| Home Federal Bank | Regional | 439 | Banks |
| Knoxville TVA Employees Credit Union | Knox | 434 | Credit union |
| Shoffner Kalthoff | Knox | 431 | Construction - mechanical & electrical contractor |
| Johnson University | Knox | 430 | 4 year private college |
| Loudon County Government | Loudon | 430 | Municipal government |
| Havco Wood Products | Monroe | 420 | Manufactures laminated wood floors for trucks |
| Radio Systems Corp | Knox | 417 | Manufactures pet containment & training products |
| Kohl's Department Stores | Regional | 415 | Department stores |
| City of Pigeon Forge | Sevier | 412 | Municipal government |
| Regions Financial Corp | Regional | 405 | Banks |
| Ripley's in the Smokies | Sevier | 405 | Ripley's area attractions |
| AMR - Rural/Metro Corp. of Tennessee | Regional | 400 | Emergency ambulance and firefighting service |
| Carlstar Group | Anderson | 400 | Manufacturing-industrial pneumatic tires for lawn, garden, heavy commercial vehicles |
| Custom Foods of America | Knox | 400 | Frozen foods |
| Melaluca, Inc. | Knox | 400 | Manufactures detergents, dental care, nutritional supplements, personal care |
| Knoxville News Sentinel | Knox | 400 | Newspaper publishing |
| Malibu Boats | Loudon | 399 | Manufactures wakeboard boats |
| Michael Dunn Center | Roane | 391 | Service-Subcontracting, shredding, recycling, janitorial laundry service, temp service |
| Brinker International | Regional | 390 | Full service restaurants: Chili's Grill & Bar |
| Lenoir City Schools | Loudon | 387 | Public school system |
| Knoxville Coca-Cola Bottling Co. | Knox | 382 | Bottling and soft drink distribution |
| BB&T Bank | Regional | 380 | Banks |
| Maryville College | Blount | 380 | 4 year private college |
| Leidos Engineering | Anderson | 375 | Engineering, energy management & clean/renewable energy consulting |
| The TJX Companies | Regional | 375 | Department stores |
| Roane County Government | Roane | 366 | Municipal government |
| YMCA of East Tennessee | Regional | 365 | Service - non-profit community organization |
| DWK Life Sciences | Roane | 360 | Manufactures laboratory glassware |
| Travelers Insurance | Knox | 356 | Personal lines insurance sales & service |
| Pepsi Beverages Co | Knox | 353 | Manufacturing & transportation-soft drink bottling & distribution |
| G.C. Services | Knox | 350 | Service-financial services customer service center, collection agency |
| House-Hasson Hardware | Knox | 350 | Transportation - hardware distribution |
| Camellia Home Health of East TN | Knox | 345 | Home healthcare |
| City of Gatlinburg | Sevier | 340 | Municipal government |
| Answer Financial Inc | Knox | 339 | Insurance customer service center |
| Bass Pro Shops | Sevier | 336 | Sporting goods store |
| City of Sevierville | Sevier | 332 | Municipal government |
| Buddy's Bar-B-Q | Regional | 325 | Fast food restaurants |
| Great Smoky Mtns National Park | Regional | 324 | Government - National Park |
| Carson-Newman University | Regional | 320 | four year private college |
| Jacobs Engineering Group | Anderson | 315 | Engineering Services |
| City of Maryville | Blount | 308 | Municipal government |
| Total Transportation of Mississippi | Loudon | 305 | Transportation - trucking |
| Whirlpool Corp | Knox | 305 | Appliance repair customer repair center; service center |
| Gold's Gym | Knox | 302 | Health club & fitness centers |
| Dillard's Inc | Regional | 300 | Department stores |
| HT Hackney Co. | Knox, Roane | 300 | Transportation - wholesale grocery distribution |
| US Foods, Inc | Blount | 300 | Transportation-wholesale grocery distribution |
| Red Lobster Hospitality | Regional | 290 | Full service restaurants |
| Johnson Family of Restaurants | Sevier | 282 | Full service restaurants: Alamo Steakhouse, Bennett's BBQ, Big Daddy's, Mad Dogs', Mama's Farmhouse |
| ARC Automotive | Knox | 266 | Manufactures automotive air bag actuators |
| Best Buy Co. | Regional | 265 | Electronics & appliances stores |
| K12 Inc | Blount | 265 | Virtual homeschooling academy support contact center |
| Stokely Hospitality Enterprises | Sevier | 255 | Full service restaurants, resorts: Applewood Farmhouse Grill; Leconte Lodge; Edgewater Hotel; Baskin Robbins |
| Tate & Lyle | Loudon | 254 | Manufactures bio-products, corn syrup, ethanol |
| Energy Solutions | Anderson | 250 | Nuclear engineering services |
| Federal-Mogul Sevierville | Sevier | 250 | Manufactures automotive engine valves |
| Norfolk Southern Corp. | Knox | 250 | Railroad freight serving 22 states |
| Yamaha Jet Boat Manufacturing | Monroe | 223 | Manufactures sport boats |
| Republic Plastics | Knox | 200 | Manufactures plastic tableware & foam plates |
| Rockford Manufacturing | Blount | 200 | Manufactures cotton, synthetic yarn, cordage |
Source: Book of Lists, community websites 2020