Largest Employers
| Company | County | Total Employees | Description |
| Y-12 National Security Complex | Roane | 11,627 | Refurbishing nuclear weapon components and storage and recycling of nuclear material. |
| Covenant Health | Regional | 11,060 | Health care system |
| Knox County Schools | Knox | 9,515 | Public education system |
| The University of Tennessee - Knoxville | Knox | 8,959 | State university |
| Wal-Mart Stores, Inc. | Regional | 6,863 | Discount stores and wholesale clubs |
| Oak Ridge National Laboratory | Roane | 5,452 | Research and Development |
| University of Tennessee Medical Center (UHS) | Knox | 5,137 | Health care system |
| Dollywood Co./Dollywood Splash Country | Sevier | 4,500 | Theme park and water park |
| Clayton Homes, Inc. | Regional | 4,262 | Manufactured and modular homes; financier & insurer of manufactured homes |
| DENSO Manufacturing Tennessee, Inc. | Blount | 4,200 | Advanced automotive components and systems |
| K-VA-T Food Stores (Food City) | Regional | 3,398 | Grocery stores and pharmacies |
| State of Tennessee - Regional Offices | Knox | 3,307 | State administrative offices |
| Sevier County Schools | Sevier | 3,000 | Local public education system |
| Tennova Healthcare | Regional | 2,900 | Health care system |
| Blount Memorial Hospital | Blount | 2,758 | Area hospital |
| Knox County Government | Knox | 2,677 | County government |
| Kroger Co. | Regional | 2,651 | Grocery stores |
| Tanger Five Oaks | Sevier | 2,500 | Retail |
| Blount County Government | Blount | 2,368 | County government |
| City of Knoxville | Knox | 2,210 | Municipal government |
| Team Health, Inc. | Knox/Blount | 2,000 | Health care providers |
| Pilot Flying J | Regional | 1,965 | Retail convenience stores and travel centers |
| Roane County Schools | Roane | 1,930 | Public education system |
| Yum! Brands RSC | Regional | 1,902 | Fast food restaurants |
| UCOR | Roane | 1,842 | Engineering, environmental management & clean-up |
| East Tennessee Children's Hospital | Knox | 1,819 | Area children's hospital |
| Cracker Barrel Old Country Store, Inc. | Regional | 1,706 | Restaurants and general stores |
| Blount County Schools | Blount | 1,701 | public education system |
| Summit Medical Group, PLLC | Regional | 1,636 | Primary care physician group |
| McGhee Tyson ANG Base | Blount | 1,609 | Air National Guard unit |
| Copper Cellar Corp. | Knox | 1,576 | Full-service restaurants |
| CVS Caremark Corp. | Knox | 1,534 | Drugstores and pharmaceutical distribution |
| Brothers Management | Knox | 1,500 | McDonald's franchise |
| United Parcel Service (UPS) | Knox | 1,450 | Shipping and delivery operation |
| England Furniture | Claiborne | 1,450 | Furniture manufacturer |
| Lowe's Home Improvement | Regional | 1,375 | Home improvement warehouses and building supplies |
| Darden Restaurants | Regional | 1,340 | Full-Service Restaurants: Red Lobster, Olive Garden, Longhorn Steakhouse, Cheddar's |
| Oak Ridge City Schools | Anderson | 1,323 | Local public education system |
| The Home Depot, Inc. | Regional | 1,278 | Home improvement warehouses and building supplies |
| Wyndham Hotel Group | Regional | 1,252 | Hotel group |
| Burleson Brands | Regional | 1,250 | Full-service restaurants: Aubrey's, Sunspot, Bistro by the Tracks, Barley's Taproom, Stefano's Pizza |
| Tennessee Valley Authority (TVA) | Knox | 1,232 | Regional power authority & development agency |
| Connor Concepts | Regional | 1,200 | Full Service Restaurants: The Chop House, Connor's Steaks & Seafood |
| JTEKT Automotive TN-Vonore Co. | Monroe | 1,200 | Automotive steering systems |
| Old Dominion Freight Line | Regional | 1,100 | Transportation - trucking |
| Knoxville Utilities Board (KUB) | Knox | 1,088 | Local utilities provider |
| U.S. Postal Service | Knox | 1,060 | Mail service |
| Anderson County Schools | Anderson | 1,050 | public education system |
| Target Corp. | Regional | 1,045 | Discount stores |
| Pellissippi State Technical Community College | Knox | 1,043 | Two-year technical community college. |
| Discovery Inc. | Knox | 1,035 | Cable networks - HGTV, Food Network, Do-It-Yourself, Fine Living & GAC |
| Jefferson County Schools | Jefferson | 1,000 | Public school system |
| Hilton Worldwide | Regional | 1,000 | Hotel group |
| Oak Ridge Associated Universities | Anderson | 1,000 | University consortium, partnerships between scientific research, government & industry |
| Newell Rubbermaid | Blount | 1,000 | Manufacturing - plastic office accessories |
| Vanderbilt Mortgage & Finance | Blount | 994 | Manufactured homes financing |
| Quality Home Health | Knox | 946 | Health Services - home health providers |
| Walgreens | Regional | 934 | Pharmacies and convenience stores |
| Restaurant Brands Intl. | Regional | 910 | Fast food restaurants: Burger King, Popeye's |
| Choice Hotels | Regional | 902 | Hotel groups |
| Keurig Green Mountain | Knox | 900 | Manufacturer/distributor of single-cup beverages & brewers |
| Eagle Bend Manufacturing | Anderson | 900 | Manufactures auto body parts |
| Dollar General Corp. | Regional | 882 | Retail trade - discount stores |
| Dine Brands Global | Regional | 879 | Full service restaurants: Applebee's, IHOP |
| Broadway Electric Service | Knox | 860 | Construction - electrical contractor |
| Arconic | Blount | 850 | Aluminum beverage can sheets |
| Helen Ross McNabb Center | Knox | 850 | Provider of mental health care, addiction recovery & social services |
| Chick-fil-A, Inc. | Regional | 840 | Fast food restaurants |
| Aisin Automotive Casting Tennessee Inc. | Anderson | 828 | Manufacture, casting, machining & assembly of timing chain covers, pistons, pumps, VVT's |
| DeRoyal Industries | Knox | 819 | Manufactures medical devices and healthcare products |
| Texas Roadhouse | Regional | 810 | Full Service Restaurants |
| InterContinental Hotels | Regional | 793 | Hotel group |
| First Horizon Bank | Regional | 782 | Banks |
| Brunswick Boat Group & Sea Ray Boats, Inc. | Knox/Monroe | 782 | Fiberglass pleasure boats |
| ADT Security Services | Knox | 780 | Security system monitoring |
| Subway | Regional | 780 | Fast food restaurants |
| Ingles Markets, Inc. | Regional | 780 | Grocery stores |
| Collier Restaurant Group | Sevier | 770 | Restaurant operations |
| SL Tennessee | Anderson | 760 | Manufacture gear shift assemblies, park brake levers, head & rear lights |
| SumiRiko Tennessee, INC. (DTR) | Claiborne | 750 | Rubber automobile hose |
| Belk, Inc. | Regional | 750 | Department stores |
| Starbucks | Regional | 728 | Coffee shops |
| Charles Blalock & Sons, Inc. | Sevier | 700 | Hot and cold mix asphalt; ready-mix concrete |
| Sitel | Anderson/Knox | 692 | Global customer interaction solutions provider |
| Kimberly-Clark Corp. | Knox/Loudon | 687 | Paper towels and bath tissue |
| Diverse Concepts, Ltd. | Regional | 666 | Full service restaurants: Blue Moose, Bullfsih, Carino's, Harrison's, Lakeside, Mellow Mushroom, Parkside, Timberwood |
| Regal Entertainment Group | Knox | 664 | Movie theaters |
| 21st Mortgage Corp. | Knox | 651 | Financing and servicing of manufactured home loans |
| Jewelry Television | Knox | 650 | Satellite-based gem/jewelry home-shopping cable network |
| Sevier County Government | Sevier | 650 | County government |
| Monroe County Schools | Monroe | 643 | Public school system |
| Radio Systems Corp | Knox | 620 | Manufactures pet containment & training products |
| Bojangles Restaurants | Regional | 613 | Fast food restaurants |
| Knoxville News Sentinel | Knox | 580 | Newspaper publishing |
| Siemens Healthcare | Knox | 573 | Clinical imaging, preclinical & biomarker solutions |
| Bloomin' Brands, Inc. | Regional | 565 | Full service restaurants: Bonefish Grill, Carrabba's, Fleming's, Outback |
| Harris Restaurant Group | Regional | 564 | Fast food restaurants |
| Publix Super Markets | Regional | 560 | Grocery stores |
| Monterey Mushrooms, Inc. | Loudon | 550 | Mushrooms |
| Comcast of the South | Knox | 540 | Broadband telecommunications services |
| U.S. Cellular Corp. | Knox | 535 | Cell phone, data systems and customer service center |
| Wilderness in the Smokies | Sevier | 530 | Hotel & water park complex |
| National Fitness Center/Court South | Knox | 526 | Health club |
| Cellular Sales | Knox | 520 | Service - largest Verizon wireless dealer |
| City of Sevierville | Sevier | 520 | Municipal government |
| Domino's Pizza | Regional | 516 | Fast food restaurants |
| Loudon County Government | Loudon | 515 | Municipal government |
| Presbyterian Homes of TN | Knox | 511 | Retirement communities and nursing homes |
| Anderson County Government | Anderson | 507 | County government |
| AT&T, Inc. | Regional | 500 | Telecommunications provider - telephone and internet. |
| Ole Smoky Distillery | Sevier | 500 | Moonshine and whiskey |
| Fee Hedrick Family Entertainment | Sevier | 500 | Entertainment attractions |
| Bush Brothers & Co | Knox, Jefferson | 500 | Manufacturing-Bush Beans and pet food |
| Commercial Vehicle Group | Monroe | 500 | Manufactures seats for heavy trucks & motorcoaches |
| Science applications International Corp. (SAIC) | Anderson | 500 | Science & engineering consulting, energy, national security |
| Waffle House | Regional | 494 | Fast food restaurants |
| Shoney's Restaurants | Knox | 480 | Full-service restaurants |
| O'Charley's Inc. | Regional | 473 | Full service restaurant |
| Truist Bank | Regional | 471 | Banks (SunTrust and BB&T) |
| Knoxville TVA Employees Credit Union | Knox | 467 | Credit union |
| Ruby Tuesday, Inc. | Blount | 465 | Full-service restaurants |
| Goodwill Industries | Regional | 451 | Service-donation centers; thrift stores |
| Grainger Co Schools | Grainger | 450 | Public education system |
| Accenture Hospitality Services | Blount | 450 | Financial shared services center for Marriott International, Inc. |
| American Book Co. | Knox, Jefferson | 450 | Wholesale trade - books |
| Exedy America Corp. | Knox | 450 | Automotive parts - torque converters |
| FedEx (Express, Freight & Ground) | Knox | 450 | Package distribution - motor freight |
| Loudon County Schools | Loudon | 447 | public education system |
| Regions Financial Corp | Regional | 446 | Banks |
| ORNL Federal Credit Union | Regional | 440 | Credit union |
| The TJX Companies | Regional | 440 | Department stores |
| Home Federal Bank | Regional | 439 | Banks |
| Krystal Co. | Regional | 435 | Fast food restaurants |
| Johnson University | Knox | 430 | 4 year private college |
| Cherokee Health Systems | Knox | 425 | Health care service |
| EdFinancial Services | Knox | 425 | Student loan processing |
| Kohl's Department Stores | Regional | 415 | Department stores |
| City of Pigeon Forge | Sevier | 414 | Municipal government |
| Ripley's in the Smokies | Sevier | 405 | Ripley's area attractions |
| City of Oak Ridge | Anderson | 404 | Municipal government |
| Elavon | Knox | 400 | Electronic payment, processing service center |
| Roane State College | Regional | 400 | 2 year community college |
| Crete Carrier Corp | Loudon | 400 | Transportation - trucking |
| Tennier Industries | Scott | 400 | Clothing |
| Custom Foods of America | Knox | 400 | Frozen foods |
| Melaluca, Inc. | Knox | 400 | Manufactures detergents, dental care, nutritional supplements, personal care |
| G.C. Services | Knox | 400 | Service-financial services customer service center, collection agency |
| Brinker International | Regional | 390 | Full service restaurants: Chili's Grill & Bar |
| Hubbell Lenoir City | Loudon | 380 | Polymer Concrete products |
| Carlstar Group | Anderson | 379 | Manufacturing-industrial pneumatic tires for lawn, garden, heavy commercial vehicles |
| DWK Life Sciences | Roane | 375 | Manufactures laboratory glassware |
| Maryville City Schools | Blount | 371 | Government - Public School System |
| Roane County Government | Roane | 366 | Municipal government |
| YMCA of East Tennessee | Regional | 365 | Service - non-profit community organization |
| Nashua Corp. | Jefferson | 360 | Paper rolls and labels |
| Shoffner Kalthoff | Knox | 357 | Construction - mechanical & electrical contractor |
| City of Maryville | Blount | 353 | Municipal government |
| Carlex Glass Co. | Monroe | 350 | Manufactures automotive glass |
| Weigel's Farm Stores Inc. | Knox | 350 | Service stations and convenience stores |
| House-Hasson Hardware | Knox | 350 | Transportation - hardware distribution |
| ConAgra | Cocke | 345 | Beans, tomato products |
| Great Smoky Mtns National Park | Regional | 338 | Government - National Park |
| Bass Pro Shops | Sevier | 336 | Sporting goods store |
| Gemtron | Monroe | 332 | Tempered and decorative glass |
| Tate & Lyle | Loudon | 331 | Manufactures bio-products, corn syrup, ethanol |
| Buddy's Bar-B-Q | Regional | 330 | Fast food restaurants |
| Maryville College | Blount | 329 | 4 year private college |
| Great Dane | Scott | 327 | Flat bed trailers |
| Carson-Newman University | Regional | 320 | four year private college |
| Leidos Engineering | Anderson | 316 | Engineering, energy management & clean/renewable energy consulting |
| Jacobs Engineering Group | Anderson | 315 | Engineering Services |
| City of Gatlinburg | Sevier | 305 | Municipal government |
| Total Transportation of Mississippi | Loudon | 305 | Transportation - trucking |
| Whirlpool Corp | Knox | 305 | Appliance repair customer repair center; service center |
| Stokely Hospitality Enterprises | Sevier | 301 | Full service restaurants, resorts: Applewood Farmhouse Grill; Leconte Lodge; Edgewater Hotel; Baskin Robbins |
| Union County Schools | Union | 300 | Public school system |
| Malibu Boats | Loudon | 300 | Manufactures wakeboard boats |
| Michael Dunn Center | Roane | 300 | Service-Subcontracting, shredding, recycling, janitorial laundry service, temp service |
| Knoxville Coca-Cola Bottling Co. | Knox | 300 | Bottling and soft drink distribution |
| Pepsi Beverages Co | Knox | 300 | Manufacturing & transportation-soft drink bottling & distribution |
| Answer Financial Inc | Knox | 300 | Insurance customer service center |
| Dillard's Inc | Regional | 300 | Department stores |
| Techmer PM LLC | Anderson | 300 | Plastic additives and compounds |
| HT Hackney Co. | Knox, Roane | 300 | Transportation - wholesale grocery distribution |
| US Foods, Inc | Blount | 300 | Transportation-wholesale grocery distribution |
| Federal-Mogul Sevierville | Sevier | 300 | Manufactures automotive engine valves |
| Yamaha Jet Boat Manufacturing | Monroe | 300 | Manufactures sport boats |
| Mastercraft Boat Co | Monroe | 296 | Manufacturing - fiberglass leisure boats |
| Red Lobster Hospitality | Regional | 290 | Full service restaurants |
| Campos Foods | Campbell | 285 | Fully-cooked frozen meats |
| Johnson Family of Restaurants | Sevier | 282 | Full service restaurants: Alamo Steakhouse, Bennett's BBQ, Big Daddy's, Mad Dogs', Mama's Farmhouse |
| Travelers Insurance | Knox | 277 | Personal lines insurance sales & service |
| Flowers Baking Co. of Knoxville | Knox | 269 | Breads, rolls, snack cakes |
| ARC Automotive | Knox | 266 | Manufactures automotive air bag actuators |
| Reinhart Foodservice ,LLC | Blount | 265 | Distributor of general line groceries to resaurants |
| Best Buy Co. | Regional | 265 | Electronics & appliances stores |
| K12 Inc | Blount | 265 | Virtual homeschooling academy support contact center |
| Lenoir City Schools | Loudon | 262 | Public school system |
| Havco Wood Products | Monroe | 250 | Manufactures laminated wood floors for trucks |
| Camellia Home Health of East TN | Knox | 250 | Home healthcare |
| Gold's Gym | Knox | 250 | Health club & fitness centers |
| Camel Manufacturing | Campbell | 250 | Sewn canvas items |
| Norfolk Southern Corp. | Knox | 250 | Railroad freight serving 22 states |
| Viskase Corporation | Loudon | 240 | Synthetic meat casings |
| Sysco Knoxville | Knox | 230 | Restaurants, hotels, schools, hospitals food distribution |
| Averitt Express | Knox | 223 | Transportation - rrucking |
| Sonoco Products Company | Cocke | 215 | Paperboard cores |
| Sonoco Products Company | Cocke | 215 | Paperboard cores |
| Lisega | Sevier | 209 | Pipe Hangers |
| Hillcrest Healthcare Communities, Inc. | Knox | 200 | Long-term care, assisted living, short-term & long-term rehab services |
| Takahata Precision America | Scott | 200 | Plastic automotive parts |
| Skier's Choice | Blount | 200 | Ski boats |
| Rockford Manufacturing | Blount | 200 | Manufactures cotton, synthetic yarn, cordage |
Source: Book of Lists, community websites 2021