Life Science and Medical Device Companies
| Company | County | Number of employees | Service |
| DeRoyal Industries | Knox | 764 | Medical device manufacturing |
| Siemens Healthcare | Knox | 534 | Clinical imaging, preclinical and biomarker solutions |
| DWK Life Sciences | Roane | 350 | Manufacturer of laboratory and scientific glassware |
| Albahealth | Roane | 170 | Fall and wound management products |
| ProNova Solutions | Knox | 95 | Proton therapy treatment systems |
| Molecular Pathology Laboratory Network Inc. | Blount | 88 | Molecular diagnostics and anatomic pathology |
| ChoiceSpine | Knox | 54 | Manufacture and distribution of spinal products |
| ABT Molecular Imaging | Blount | 34 | Positron Emission Tomography (P.E.T.) cyclotron equipment |
| East Tennessee Clinical Research | Roane | 27 | Veterinary pharmaceutical development |
| Materials and Chemistry Laboratory | Anderson | 17 | Commercial applied research company |
| Genera Energy | Monroe | 15 | Integrated biomass feedstock supply chain solutions, energy crop production |
| Microbial Insights | Knox | 15 | Environmental remediation, microbial induced corrosion, microbial source tracking |
| Daxor Corp. | Anderson | 15 | Medical device & pharmaceutical manufacturer |
| Arkis BioSciences | Knox | 11 | Surgical tools and implantables |
| Assured Bio Labs | Anderson | 10 | Microbial detection, DNA probes, indoor air quality, quantitative PCR, fluorescent spectroscopy, microscopy |
| 490 BioTech | Knox | 8 | Biomedical imaging, custom-designed human cell lines for improved drug testing and disease management |
| EDP Biotech | Knox | 7 | Colorectal cancer diagnostics and medical devices |
| Phenotype Screening Corp. | Knox | 4 | Plant root imaging services, X-ray equipment for plant root imaging, plant growth trials, nematode resistance screening |
| Prisma Renewable Composites | Knox | 4 | Biomass fractionation technologies and processes |
| Provectus Biopharmaceuticals | Knox | 4 | Pharmaceuticals aimed at treating cancer (melanoma, liver, breast) and skin diseases |
Source: Book of Lists, community websites 2019