Life Science and Medical Device Companies
| Company | County | Number of employees | Service |
| DeRoyal Industries | Knox | 747 | Medical device manufacturing |
| Siemens Healthcare | Knox | 512 | Clinical imaging, preclinical and biomarker solutions |
| Kimble Chase Life Science and Research | Roane | 350 | Manufacturer of laboratory and scientific glassware |
| Albahealth | Roane | 175 | Fall and wound management products |
| Molecular Pathology Laboratory Network Inc. | Blount | 110 | Molecular diagnostics and anatomic pathology |
| ProNova Solutions | Knox | 100 | Proton therapy treatment systems |
| DenTek Oral Care | Blount | 70 | Dental guards, floss picks, interdental brushes, dental first aid kit, dry mouth and canker sore relief |
| ChoiceSpine | Knox | 46 | Manufacture and distribution of spinal products |
| East Tennessee Clinical Research | Roane | 22 | Veterinary pharmaceutical development |
| ABT Molecular Imaging | Blount | 27 | Positron Emission Tomography (P.E.T.) cyclotron equipment |
| Genera Energy | Monroe | 18 | Integrated biomass feedstock supply chain solutions, energy crop production |
| Materials and Chemistry Laboratory | Anderson | 20 | Commercial applied research company |
| Microbial Insights | Knox | 16 | Environmental remediation, microbial induced corrosion, microbial source tracking |
| Daxor Corp. | Anderson | 15 | Medical device & pharmaceutical manufacturer |
| Assured Bio Labs | Anderson | 14 | Microbial detection, DNA probes, indoor air quality, quantitative PCR, fluorescent spectroscopy, microscopy |
| Arkis BioSciences | Knox | 10 | Surgical tools and implantables |
| EDP Biotech | Knox | 5 | Colorectal cancer diagnostics and medical devices |
| 490 BioTech | Knox | 9 | Biomedical imaging, custom-designed human cell lines for improved drug testing and disease management |
| Phenotype Screening Corp. | Knox | 4 | Plant root imaging services, X-ray equipment for plant root imaging, plant growth trials, nematode resistance screening |
| TennEra | Knox | 4 | Biomass fractionation technologies and processes |
| Provectus Biopharmaceuticals | Knox | 4 | Pharmaceuticals aimed at treating cancer (melanoma, liver, breast) and skin diseases |
Source: Book of Lists, community websites 2018