Life Science and Medical Device Companies
| Company | County | Number of employees | Service |
| DeRoyal Industries | Knox | 819 | Medical device manufacturing |
| Siemens Healthcare | Knox | 573 | Clinical imaging, preclinical and biomarker solutions |
| DWK Life Sciences | Roane | 360 | Manufacturer of laboratory and scientific glassware |
| Scapa Healthcare | Knox | 175 | Medical device converting, adhesive dressings |
| Albahealth | Roane | 130 | Fall and wound management products |
| ProNova Solutions | Knox | 95 | Proton therapy treatment systems |
| ChoiceSpine | Knox | 64 | Manufacture and distribution of spinal products |
| Molecular Pathology Laboratory Network Inc. | Blount | 56 | Molecular diagnostics and anatomic pathology |
| Genera Energy | Monroe | 45 | Integrated biomass feedstock supply chain solutions, energy crop production |
| East Tennessee Clinical Research | Roane | 25 | Veterinary pharmaceutical development |
| BioPet Vet Lab | Knox | 20 | DNA testing and patented technologies for dogs and livestock |
| Materials and Chemistry Laboratory | Anderson | 20 | Commercial applied research company |
| Microbial Insights | Knox | 19 | Environmental remediation, microbial induced corrosion, microbial source tracking |
| Daxor Corp. | Anderson | 15 | Medical device & pharmaceutical manufacturer |
| Assured Bio Labs | Anderson | 15 | Microbial detection, DNA probes, indoor air quality, quantitative PCR, fluorescent spectroscopy, microscopy |
| Arkis BioSciences | Knox | 10 | Surgical tools and implantables |
| 490 BioTech | Knox | 8 | Biomedical imaging, custom-designed human cell lines for improved drug testing and disease management |
| EDP Biotech | Knox | 6 | Colorectal cancer diagnostics and medical devices |
| Prisma Renewable Composites | Knox | 5 | Biomass fractionation technologies and processes |
| Phenotype Screening Corp. | Knox | 4 | Plant root imaging services, X-ray equipment for plant root imaging, plant growth trials, nematode resistance screening |
| Provectus Biopharmaceuticals | Knox | 3 | Pharmaceuticals aimed at treating cancer (melanoma, liver, breast) and skin diseases |
Source: Book of Lists, community websites 2021